DR. ASHUTOSH SINGH

Assistant Professor

LIPID BIOCHEMISTRY AND INFECTIOUS DISEASES

Biochemistry

Basic Details

DR. ASHUTOSH SINGH
52012644
Assistant Professor
Biochemistry

Qualification Details

S.No. Qualification Name Of University Passing Year
1 Bachelor of Science University of Lucknow 2005
2 Master of Science University of Lucknow 2007
3 Doctor of Philosophy Jawaharlal Nehru University 2012

Positions Held

S.No. Employer Designation Employment Period
Date from Date to
1 O4292DBT, Govt. of India Senior Research Fellow 31/01/2013 30/10/2013
2 O4293State University of New York Postdoctoral Associate 06/12/2013 18/04/2016
3 O4294University of Lucknow Assistant Professor 22/04/2016 Presently Working

Academic Details

Recent Significant Publications, Articles, Cases

S.No. Title Journal Volume/Issue Year
1 O17620Benzo (a)pyrene exposure reduces CD54 expression on alveolar macrophages and alters apoptosis and inflammatory responses in the lungs Indian Journal of Biochemistry & Biophysics DOI: 10.56042/ijbb.v62i6.10703 2025
2 O17621Bisphenol-A-induced ovarian cancer: Changes in epithelial diversity, apoptosis, antioxidant and anti-inflammatory mechanisms Reproductive Toxicology 135:108909 2025
3 O17689Bisphenol-A-induced ovarian cancer: Changes in epithelial diversity, apoptosis, antioxidant and anti-inflammatory mechanisms Reproductive Toxicology https://doi.org/10.1016/j.reprotox.2025.108909 2025
4 O17688Dermatophytosis in context of Trichophyton rubrum: host defense mechanisms, virulence factors, and treatment innovations Molecular Biology Reports https://doi.org/10.1007/s11033-025-10744-4 2025
5 O17619Diversity in the lipidomes of Trichophyton rubrum, Trichophyton interdigitale and Trichophyton tonsurans, and their phenotypes Microbial Pathogenesis https://doi.org/10.1016/j.micpath.2025.1 2025
6 O17690Mass Spectrometry-Based Lipidomics Reveals a Strong Connection Between Lipid Homeostasis and Iron Acquisition in Candida albicans Lipids https://doi.org/10.1002/lipd.12455 2025
7 O17691Multi-Omics Analysis of Experimentally Evolved Candida auris Isolates Reveals Modulation of Sterols, Sphingolipids, and Oxidative Stress in Acquired Amphotericin B Resistance Molecular microbiology https://doi.org/10.1111/mmi.15379 2025
8 O17687Optimized Purification Processes for Isolation and Modification of Oligosaccharides from Rathi Cow’s Milk Biol. Life Sci. Forum https://doi.org/10.3390/blsf2024040021 2025
9 O17686The experimentally evolved fluconazole-resistant clade II isolates of Candidozyma auris exhibit a distinct lipid compositional landscape, highlighting intraclade sphingolipid heterogeneity FEMS Yeast Research https://doi.org/10.1093/femsyr/foaf030 2025
10 O17636A Comprehensive Analysis of the Lipidomic Signatures in Rhizopus delemar Journal of Fungi doi: 10.20944/preprints202409.0325.v1 2024
11 O17624Aflatoxin B1 administration causes inflammation and apoptosis in the lungs and spleen Toxicon 107581, https://doi.org/10.1016/j.toxicon.2023.1 2024
12 O17632Application of the traditional spectrophotometric method for measuring cellular and free iron pools of Candida albicans Science and Innovation (Scientific Conferences) https://doi.org/10.5281/zenodo.13847121 2024
13 O17623Benzo (A) Pyrene exposure alters Alveolar Epithelial and Macrophage Cells diversity and induces antioxidant responses in lungs Toxicology Reports https://doi.org/10.1016/j.toxrep.2024.10 2024
14 O17637Bisphenol A-induced oxidative stress increases the production of ovarian cancer stem cells in mice Reproductive Toxicology https://doi.org/10.1016/j.reprotox.2024. 2024
15 O17634Comparative evaluation of different methods for spore’s isolation from Trichophyton rubrum cultures Science and Innovation (Scientific Conferences) https://doi.org/10.5281/zenodo.13829100 2024
16 O17631Comparative Evaluation of Milk Oligosaccharides Isolated and Fractionated from Indigenous Rathi Cow Milk for Anti-Oxidant and Anti-Adhesive Properties Proceedings doi.org/10.3390/proceedings2024105047 2024
17 O17628Decoding the Complex Terrain of Candida tropicalis -Induced Candidiasis: Insights into Epidemiology, Infection Mechanisms,Therapeutics, and Drug Resistance Recent Advances in Human Fungal Diseases ISBN 978-981-97-4908-9 2024
18 O17638Drug resistance in Mycobacterium tuberculosis: an evolutionary perspective and its adaptation to the lung microenvironment The Microbe doi.org/10.1016/j.microb.2024.100189 2024
19 O17635Future perspective of metabolomic study in dermatophyte cultures Science and Innovation (Scientific Conferences) https://doi.org/10.5281/zenodo.13832344 2024
20 O17627Impact of sphingolipid synthesis inhibition on the drug susceptibility patterns of Trichophyton species Diagnostic Microbiology & Infectious Disease 116283 2024
21 O17622Modulation of redox metabolism, CD147, and CD47 expression with the maturation of hematopoietic stem cells in bone marrow Indian Journal of Hematology and Blood Transfusion https://doi.org/10.1007/s12288-024-01911-x 2024
22 O17629Mucormycosis Infection and Methods of Detection: An Overview Human Fungal Diseases https://doi.org/10.1201/9781032642864 2024
23 O17625Remodeling of membrane lipid homeostasis in azole resistant isolates of Candida albicans Chemical Biology Letters 11(2), 658 2024
24 O17626Sphingolipid diversity in Candida auris: unraveling interclade and drug resistance fingerprints FEMS Yeast Research foae008 2024
25 O17633Suitability of Ftr2 (iron permease) for screening of antifungal compounds against Candida albicans Science and Innovation (Scientific Conferences) https://doi.org/10.5281/zenodo.13831907 2024
26 O17630Understanding Trichophyton-Mediated Dermatophytosis: Key Factors and Treatment Insights Human Fungal Diseases https://doi.org/10.1201/9781032642864 2024
27 O17642Beyond Membrane Components: Uncovering the Intriguing World of Fungal Sphingolipid Synthesis and Regulation Research in Microbiology 174(7), 104087, https://doi.org/10.1016/j.resmic.2023.104087 2023
28 O17640Metabolomics and therapeutic potential of Ophiocordyceps sinensis Phytochemical Genomics: Plant Metabolomics and Medicinal Plant Genomics 319–342; DOI:10.1007/978-981-19-5779-6_12 2023
29 O17639Microevolution of clade II isolates of Candida auris highlights multifaceted intra-clade heterogeneity in acquiring resistance towards amphotericin B bioRxiv https://doi.org/10.1101/2023.09.20.558730 2023
30 O17641Polydispersed Acid-Functionalized Single-Walled Carbon Nanotubes Induced the Integrin-Associated Protein (CD47) and Basigin (CD147) Expression and Modulated the Antioxidant Gene Expression in Erythroi BioNanoScience doi.org/10.1007/s12668-023-01071-8 2023
31 O17646Epidemiology and Therapeutics strategies to treat human pathogenic coronaviruses disease Novel Corona Virus (COVID-19) Past, Present and Future, UCOST, ISBN: 978-93-93097-97-2 361-372 2022
32 O17643High-Throughput Phospholipidomics of Candida Cells: From Sample Preparation to Data Analysis Candida Species: Methods and Protocols 127-140 2022
33 O17644Inositol Phosphoryl Transferase, Ipt1, Is a Critical Determinant of Azole Resistance and Virulence Phenotypes in Candida glabrata Journal of Fungi 8(7), 651; https://doi.org/10.3390/jof80 2022
34 O17645Paraquat treatment modulates the stress erythropoiesis response in bone marrow and liver of splenectomized mice Chemical Biology Letters 9,2:306 2022
35 O17650Cholesterol and sphingomyelin are critical for Fcγ receptor-mediated phagocytosis of Cryptococcus neoformans by macrophages Journal of Biological Chemistry https://doi.org/10.1016/j.jbc.2021.10141 2021
36 O17648Lipid Structure, Function, and Lipidomic Applications In: Hameed S., Fatima Z. (eds) Integrated Omics Approaches to Infectious Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-16-0691-5_24 2021
37 O17647Mass Spectrometric Analysis of Bioactive Sphingolipids in Fungi In: Hsu FF. (eds) Mass Spectrometry-Based Lipidomics. Methods in Molecular Biology, Humana, New York, NY. 2306, https://doi.org/10.1007/978-1-0716-1410-5_16 2021
38 O17649Sphingolipidomics of drug resistant Candida auris clinical isolates reveal distinct sphingolipid species signatures Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1866(1):158815 2021
39 O17656A detailed lipidomic study of human pathogenic fungi Candida auris FEMS Yeast Research https://doi.org/10.1093/femsyr/foaa045 2020
40 O17653Analysis of Membrane Lipids *Book, Springer, New York, NY 1, ISBN:978-1-0716-0631-5; 2020
41 O17652Analysis of Sterols by Gas Chromatography–Mass Spectrometry Analysis of Membrane Lipids, Springer, New York, NY 1:83-101, ISBN: 978-1-0716-0631-5 2020
42 O17651Background of Membrane Lipids Analysis of Membrane Lipids, Springer, New York, NY 1:1-11, ISBN: 78-1-0716-0631-5 2020
43 O17654Nanomaterial-Assisted Mass Spectrometry: An Evolving Cutting-Edge Technique NanoBioMedicine. Springer, Singapore https://doi.org/10.1007/978-981-32-9898-9_19; pp 453-464 2020
44 O17655Splenectomy modulates the erythrocyte turnover and Basigin (CD147) expression in mice Indian Journal of Hematology and Blood Transfusion https://doi.org/10.1007/s12288-020-01272-1 2020
45 O17659Lipidomics Approaches: Applied to the Study of Pathogenesis in Candida Species Yeasts in Biotechnology and Human Health. Progress in Molecular and Subcellular Biology, Springer Cham 58:195-215 2019
46 O17657Sphingolipid Biosynthetic Pathway is Crucial for Growth, Biofilm Formation and Membrane Integrity of Scedosporium boydii Future Medicinal Chemistry https://doi.org/10.4155/fmc-2019-0186 2019
47 O17662Azole resistance in a Candida albicans mutant lacking the ABC transporter CDR6/ROA1 depends on TOR signaling Journal of Biological Chemistry 293(2):412-432 2018
48 O17661Paraquat treatment modulates Integrin associated Protein (CD47) and Basigin (CD147) expression and mitochondrial potential on erythroid cells in mice Environmental Toxicology and Pharmacology 58:37-44 2018
49 O17660The role of ceramide synthases in the pathogenicity of Cryptococcus neoformans Cell Reports 22(6):1392-1400 2018
50 O17665Analysis of sphingolipids, sterols and phospholipids in human pathogenic Cryptococcus strains Journal of Lipid Research 58(10):2017-2036 2017
51 O17664Changes in Glucosylceramide Structure Affect Virulence and Membrane Biophysical Properties of Cryptococcus neoformans Biochimica et Biophysica Acta - Biomembranes 1859:2224–2233 2017
52 O17663Comparison of TLC and GCMS techniques for steryl glucoside analysis International Journal of Scientific Research Letters 1(1):17-20 2017
53 O17667Insights into Candida lipids Candida albicans: Cellular and Molecular Biology, Springer 978-3-319-50409-4 2017
54 O17666The effect of sterol structure upon clathrin-mediated and clathrin-independent endocytosis Journal of Cell Science 130:2682-2695 2017
55 O17669Functional characterization of the Aspergillus nidulans glucosylceramide pathway reveals that LCB Δ8‐desaturation and C9‐methylation are relevant to filamentous growth, lipid raft localization and Psd Molecular Microbiology 102(3):488-505 2016
56 O17671Glucosylceramide Administration as a Vaccination Strategy in Mouse Models of Cryptococcosis PLOS ONE 11(4):e0153853 2016
57 O17672Pleiotropic effects of a vacuolar ABC transporter MLT1 of Candida albicans on cell function and virulence Biochemical Journal 473(11):1537-52 2016
58 O17673Sphingolipidomics: an important mechanistic tool for studying fungal pathogens Frontiers in Microbiology 7:501 2016
59 O17668Sphingolipids: the most recent target for fungal infections treatment Future Medicinal Chemistry 8(12):1469-1484 2016
60 O17670The Aspergillus fumigatus SchASCH9 kinase modulates SakAHOG1 MAP kinase activity and it is essential for virulence Molecular Microbiology 102(4):642-671 2016
61 O17676Identification of a new class of antifungals targeting the synthesis of fungal sphingolipids mBio 6(3):e00647 2015
62 O17674Qualitative and quantitative measurements of sphingolipids by mass spectrometry Bioactive Sphingolipids in Cancer Biology and Therapy (Springer Science) 978-3-319-20750-6 2015
63 O17675Role of Sterylglucosidase 1 (Sgl1) on the pathogenicity of Cryptococcus neoformans: potential applications for vaccine development Frontiers in Microbiology 6:836 2015
64 O17677An assessment of growth media enrichment on lipid metabolome and the concurrent phenotypic properties of Candida albicans PLOS ONE 11:e113664 2014
65 O17681Curcumin targets cell wall integrity via calcineurin mediated signaling in Candida albicans Antimicrobial Agents and Chemotherapy 58(1):167-75 2014
66 O17678Inositol Phosphosphingolipid Phospholipase C1 Regulates Plasma Membrane ATPase (Pma1) Stability in Cryptococcus neoformans FEBS Letters 558(21):3932-3938 2014
67 O17680Novel Role of a Family of Major Facilitator Transporters in Biofilm Development and Virulence of Candida albicans Biochemical Journal 460(2):223-235 2014
68 O17679What are the opportunities and responsibilities of scientists to communicate their research at home and abroad? Cultures (ASM, USA) 1(2):52-59 2014
69 O17618Lipidomics and in vitro azole resistance in Candida albicans OMICS 17(2):84-93 2013
70 O17658Lipids of Candida albicans and their role in multidrug resistance Current Genetics 59(4):243-50 2013
71 O17682A key structural domain of the Candida albicans Mdr1 protein Biochemical Journal 445(3):313-22 2012
72 O17683Comparative lipidomics in clinical isolates of Candida albicans reveal crosstalk between mitochondria, cell wall integrity and azole resistance PLOS ONE 7(6):e39812 2012
73 O17685Lipidome analysis reveals antifungal polyphenol curcumin affects membrane lipid homeostasis Frontiers in Bioscience (Elite Ed) 4:1195-209 2012
74 O17684The antifungal effect of Malachite Green on Candida albicans involves multiple cellular pathways and is regulated by transcription regulators UPC2 and STP2 Antimicrobial Agents and Chemotherapy 56(1):495-506 2012

Conferences, Seminars &Talks

S.No. Details Year.
1 O15958“Recent Advances in Biochemistry and Biotechnology (RABB 2024)”, at University of Lucknow, on 16th March, 2024 2024
2 O15959“Functional Biology and Molecular Interactions (FBMI 2023)”, at University of Lucknow, on 28th January, 2023 2023
3 O15980“Yeast India 2023: Fundamental to Applications of Yeast and Fungi” held from March 10-13, 2023 at IISER Mohali 2023
4 O15960“Recent Advances in Biochemistry and Biotechnology (RABB 2021)”, at University of Lucknow, on 20th March, 2021 2021
5 O15961FEMS Yeast Research Webinar on Yeast Lipids, FEMS, on 3rd June, 2021 2021
6 O15962“Two–day Workshop on finalization of Teaching Learning Resources for Life-science Teachers”, at NIEPA, New Delhi, on 16-17 Jan, 2020 2020
7 O15963International conference on “2nd Lipids in the Forefront: Lot more to discover” organized by Amity University, Gurgaon, from 12th – 13th December, 2019 2019
8 O15964“DST Inspire Camp” organized by S.R.M.S.C.E.T. Unnao, on September 2nd, 2019 2019
9 O15965Refresher Course in Chemistry & Bio-Chemistry held at Human Resource Development Center, University of Lucknow, Lucknow, Uttar Pradesh, India, August 17-31, 2019 2019
10 O15966Refresher Course in Chemistry & Bio-Chemistry held at Human Resource Development Center, University of Lucknow, Lucknow, Uttar Pradesh, India, August 17-31, 2019 2019
11 O15967"10th Conference on Yeast Biology" jointly organized by Jawaharlal Nehru University and Amity University, Gurgaon, held at JNU, New Delhi, India, 8th – 11th February, 2018 2018
12 O15968International Conference on “Conference on Functional Biology and Molecular Interactions (FBMI-2017)” held at University of Lucknow, Lucknow, Uttar Pradesh, India, 20th – 22nd December, 2017 2017
13 O15969“127th Orientation Program” (UGC, Govt. of India sponsored) held at Human Resource Development Center, University of Lucknow, Lucknow, Uttar Pradesh, India, 1st – 29th November, 2017 2017
14 O159706th National Conference on “Nanomaterials and Nanotechnology (NATCON NAMTECH VI)” held at Department of Physics, University of Lucknow, Lucknow, Uttar Pradesh, India, 11th – 13th February, 2017 2017
15 O15971National Conference “Lipids in forefront: A lot more to discover” held at Amity University, Panchgaon, Manesar, Gurgaon-122 413 (Haryana), India, 14th – 15th December, 2016 2016
16 O15972“57th Annual Conference & International Symposium of Association of Microbiologists of India” held at Gauhati University, Guwahati, India, 24th – 27th November, 2016 2016
17 O15973“National Seminar on: Paradigm Shifts in Biochemistry: Emerging Trends and New Vistas” held at University of Lucknow, Lucknow, UP, India, 10th September, 2016 2016
18 O15974“9th ICB&DD Symposium” held at Stony Brook University, Stony Brook, USA, 8th October, 2015 2015
19 O15975“114th ASM General Meeting” held at Boston, Massachusetts, USA, 17th – 20th May, 2014 2014
20 O15976“113th ASM General Meeting” held at Denver, Colorado, USA, 18th – 21st May, 2013 2013
21 O15977Workshop on ‘Scientific Writing and Bioethics’ held at School of Life Sciences, Jawaharlal Nehru University, New Delhi, India, 20th - 21st September, 2012 2012
22 O15978“Workshop on GCMS” held at Advanced Instrumentation Research Facility, Jawaharlal Nehru University, New Delhi, India, 13 – 14th August, 2012 2012
23 O15979“11th ASM Conference on Candida and Candidiasis” held at San Francisco, CA, USA, 29th March – 2nd April, 2012 2012

Awards & Recognitions

S.No. Name Of Awards Year.
1 O15954ASM Young Ambassador to India, American Society for Microbiology, USA 2013
2 O15955ASM Student travel award, American Society for Microbiology, USA 2012
3 O15957Senior Research Fellowship, Council of Scientific & Industrial Research, India 2012
4 O15956Travel award from Department of Science & Technology, India 2012

Academic/Administrative Services to the University

S.No. Details
1 O11887Member, Faculty Board, Faculty of Science, University of Lucknow (Present)
2 O11888Additional Dean, Research Cell, University of Lucknow (Past)
3 O11889Member, Board of Studies, Department of Biochemistry (Present)
4 O11890Assistant Proctor, University of Lucknow (Past)
5 O11891President, Table Tennis Club, University of Lucknow (Past)

Teaching Areas / Specialization

S.No. Details
1 O11875Biosafety and Bioethics
2 O11876Biochemical Techniques
3 O11877Immunology
4 O11878Cell Biology
5 O11879Fungal Infections
6 O11880Sphingolipids

Research Areas & Interests

S.No. Details
1 O11881DST Grant 2023: High throughput Lipidomics of Mucorales (black fungus) to determine specific lipid fingerprints associated with their infection and drug resistance
2 O11882CoE, UP Higher Education 2021: Targeting the lipid and iron homeostasis of Candida albicans to develop treatment approaches
3 O11883ASM, US 2009: Lipidomics of Candida in antifungal resistance
4 O11884ICMR Grant 2019: Manipulation of lipid biosynthesis to treat Trichophyton rubrum mediated onchomycosis
5 O11885DBT Grant 2020: A Mass Spectrometric Approach to Unravel the Landscape of Sphingolipids as Major Signaling Determinants of Drug Resistance and Virulence in Emerging Human Fungal Pathogen Candida auris
6 O11886Research & Development Grant, UP Higher Education 2024: Repurposing anti-cancer natural phytochemicals to treat human pathogenic Trichophyton species

Consulting Areas

S.No. Consulting Areas
1 O11892Sphingolipids
2 O11893Small and complex molecule mass spectrometry
3 O11894Human fungal infections
4 O11895Lipid metabolism