DR. ASHUTOSH SINGH

Assistant Professor

LIPID BIOCHEMISTRY AND INFECTIOUS DISEASES

Biochemistry

Basic Details

DR. ASHUTOSH SINGH
52012644
Assistant Professor
Biochemistry

Qualification Details

S.No. Qualification Name Of University Passing Year
1 Bachelor of Science University of Lucknow 2005
2 Master of Science University of Lucknow 2007
3 Doctor of Philosophy Jawaharlal Nehru University 2012

Positions Held

S.No. Employer Designation Employment Period
Date from Date to
1 O3332DBT, Govt. of India Senior Research Fellow 31/01/2013 30/10/2013
2 O3333State University of New York Postdoctoral Associate 06/12/2013 18/04/2016
3 O3334University of Lucknow Assistant Professor 22/04/2016 Presently Working

Academic Details

Recent Significant Publications, Articles, Cases

S.No. Title Journal Volume/Issue Year
1 O12425Aflatoxin B1 administration causes inflammation and apoptosis in the lungs and spleen Toxicon 107581, https://doi.org/10.1016/j.toxicon.2023.1 2024
2 O12476Impact of sphingolipid synthesis inhibition on the drug susceptibility patterns of Trichophyton species Diagnostic Microbiology & Infectious Disease 116283 2024
3 O12426Remodeling of membrane lipid homeostasis in azole resistant isolates of Candida albicans Chemical Biology Letters 11(2), 658 2024
4 O12475Sphingolipid diversity in Candida auris: unraveling interclade and drug resistance fingerprints FEMS Yeast Research foae008 2024
5 O12430Beyond Membrane Components: Uncovering the Intriguing World of Fungal Sphingolipid Synthesis and Regulation Research in Microbiology 174(7), 104087, https://doi.org/10.1016/j.resmic.2023.104087 2023
6 O12428Metabolomics and therapeutic potential of Ophiocordyceps sinensis Phytochemical Genomics: Plant Metabolomics and Medicinal Plant Genomics 319–342; DOI:10.1007/978-981-19-5779-6_12 2023
7 O12427Microevolution of clade II isolates of Candida auris highlights multifaceted intra-clade heterogeneity in acquiring resistance towards amphotericin B bioRxiv https://doi.org/10.1101/2023.09.20.558730 2023
8 O12429Polydispersed Acid-Functionalized Single-Walled Carbon Nanotubes Induced the Integrin-Associated Protein (CD47) and Basigin (CD147) Expression and Modulated the Antioxidant Gene Expression in Erythroi BioNanoScience doi.org/10.1007/s12668-023-01071-8 2023
9 O12434Epidemiology and Therapeutics strategies to treat human pathogenic coronaviruses disease Novel Corona Virus (COVID-19) Past, Present and Future, UCOST, ISBN: 978-93-93097-97-2 361-372 2022
10 O12431High-Throughput Phospholipidomics of Candida Cells: From Sample Preparation to Data Analysis Candida Species: Methods and Protocols 127-140 2022
11 O12432Inositol Phosphoryl Transferase, Ipt1, Is a Critical Determinant of Azole Resistance and Virulence Phenotypes in Candida glabrata Journal of Fungi 8(7), 651; https://doi.org/10.3390/jof80 2022
12 O12433Paraquat treatment modulates the stress erythropoiesis response in bone marrow and liver of splenectomized mice Chemical Biology Letters 9,2:306 2022
13 O12438Cholesterol and sphingomyelin are critical for Fcγ receptor-mediated phagocytosis of Cryptococcus neoformans by macrophages Journal of Biological Chemistry https://doi.org/10.1016/j.jbc.2021.10141 2021
14 O12436Lipid Structure, Function, and Lipidomic Applications In: Hameed S., Fatima Z. (eds) Integrated Omics Approaches to Infectious Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-16-0691-5_24 2021
15 O12435Mass Spectrometric Analysis of Bioactive Sphingolipids in Fungi In: Hsu FF. (eds) Mass Spectrometry-Based Lipidomics. Methods in Molecular Biology, Humana, New York, NY. 2306, https://doi.org/10.1007/978-1-0716-1410-5_16 2021
16 O12437Sphingolipidomics of drug resistant Candida auris clinical isolates reveal distinct sphingolipid species signatures Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1866(1):158815 2021
17 O12444A detailed lipidomic study of human pathogenic fungi Candida auris FEMS Yeast Research https://doi.org/10.1093/femsyr/foaa045 2020
18 O12441Analysis of Membrane Lipids *Book, Springer, New York, NY 1, ISBN:978-1-0716-0631-5; 2020
19 O12440Analysis of Sterols by Gas Chromatography–Mass Spectrometry Analysis of Membrane Lipids, Springer, New York, NY 1:83-101, ISBN: 978-1-0716-0631-5 2020
20 O12439Background of Membrane Lipids Analysis of Membrane Lipids, Springer, New York, NY 1:1-11, ISBN: 78-1-0716-0631-5 2020
21 O12442Nanomaterial-Assisted Mass Spectrometry: An Evolving Cutting-Edge Technique NanoBioMedicine. Springer, Singapore https://doi.org/10.1007/978-981-32-9898-9_19; pp 453-464 2020
22 O12443Splenectomy modulates the erythrocyte turnover and Basigin (CD147) expression in mice Indian Journal of Hematology and Blood Transfusion https://doi.org/10.1007/s12288-020-01272-1 2020
23 O12446Lipidomics Approaches: Applied to the Study of Pathogenesis in Candida Species Yeasts in Biotechnology and Human Health. Progress in Molecular and Subcellular Biology, Springer Cham 58:195-215 2019
24 O12445Sphingolipid Biosynthetic Pathway is Crucial for Growth, Biofilm Formation and Membrane Integrity of Scedosporium boydii Future Medicinal Chemistry https://doi.org/10.4155/fmc-2019-0186 2019
25 O12449Azole resistance in a Candida albicans mutant lacking the ABC transporter CDR6/ROA1 depends on TOR signaling Journal of Biological Chemistry 293(2):412-432 2018
26 O12448Paraquat treatment modulates Integrin associated Protein (CD47) and Basigin (CD147) expression and mitochondrial potential on erythroid cells in mice Environmental Toxicology and Pharmacology 58:37-44 2018
27 O12447The role of ceramide synthases in the pathogenicity of Cryptococcus neoformans Cell Reports 22(6):1392-1400 2018
28 O12452Analysis of sphingolipids, sterols and phospholipids in human pathogenic Cryptococcus strains Journal of Lipid Research 58(10):2017-2036 2017
29 O12451Changes in Glucosylceramide Structure Affect Virulence and Membrane Biophysical Properties of Cryptococcus neoformans Biochimica et Biophysica Acta - Biomembranes 1859:2224–2233 2017
30 O12450Comparison of TLC and GCMS techniques for steryl glucoside analysis International Journal of Scientific Research Letters 1(1):17-20 2017
31 O12454Insights into Candida lipids Candida albicans: Cellular and Molecular Biology, Springer 978-3-319-50409-4 2017
32 O12453The effect of sterol structure upon clathrin-mediated and clathrin-independent endocytosis Journal of Cell Science 130:2682-2695 2017
33 O12456Functional characterization of the Aspergillus nidulans glucosylceramide pathway reveals that LCB Δ8‐desaturation and C9‐methylation are relevant to filamentous growth, lipid raft localization and Psd Molecular Microbiology 102(3):488-505 2016
34 O12458Glucosylceramide Administration as a Vaccination Strategy in Mouse Models of Cryptococcosis PLOS ONE 11(4):e0153853 2016
35 O12460Pleiotropic effects of a vacuolar ABC transporter MLT1 of Candida albicans on cell function and virulence Biochemical Journal 473(11):1537-52 2016
36 O12459Sphingolipidomics: an important mechanistic tool for studying fungal pathogens Frontiers in Microbiology 7:501 2016
37 O12455Sphingolipids: the most recent target for fungal infections treatment Future Medicinal Chemistry 8(12):1469-1484 2016
38 O12457The Aspergillus fumigatus SchASCH9 kinase modulates SakAHOG1 MAP kinase activity and it is essential for virulence Molecular Microbiology 102(4):642-671 2016
39 O12463Identification of a new class of antifungals targeting the synthesis of fungal sphingolipids mBio 6(3):e00647 2015
40 O12461Qualitative and quantitative measurements of sphingolipids by mass spectrometry Bioactive Sphingolipids in Cancer Biology and Therapy (Springer Science) 978-3-319-20750-6 2015
41 O12462Role of Sterylglucosidase 1 (Sgl1) on the pathogenicity of Cryptococcus neoformans: potential applications for vaccine development Frontiers in Microbiology 6:836 2015
42 O12464An assessment of growth media enrichment on lipid metabolome and the concurrent phenotypic properties of Candida albicans PLOS ONE 11:e113664 2014
43 O12468Curcumin targets cell wall integrity via calcineurin mediated signaling in Candida albicans Antimicrobial Agents and Chemotherapy 58(1):167-75 2014
44 O12465Inositol Phosphosphingolipid Phospholipase C1 Regulates Plasma Membrane ATPase (Pma1) Stability in Cryptococcus neoformans FEBS Letters 558(21):3932-3938 2014
45 O12467Novel Role of a Family of Major Facilitator Transporters in Biofilm Development and Virulence of Candida albicans Biochemical Journal 460(2):223-235 2014
46 O12466What are the opportunities and responsibilities of scientists to communicate their research at home and abroad? Cultures (ASM, USA) 1(2):52-59 2014
47 O12470Lipidomics and in vitro azole resistance in Candida albicans OMICS 17(2):84-93 2013
48 O12469Lipids of Candida albicans and their role in multidrug resistance Current Genetics 59(4):243-50 2013
49 O12471A key structural domain of the Candida albicans Mdr1 protein Biochemical Journal 445(3):313-22 2012
50 O12472Comparative lipidomics in clinical isolates of Candida albicans reveal crosstalk between mitochondria, cell wall integrity and azole resistance PLOS ONE 7(6):e39812 2012
51 O12474Lipidome analysis reveals antifungal polyphenol curcumin affects membrane lipid homeostasis Frontiers in Bioscience (Elite Ed) 4:1195-209 2012
52 O12473The antifungal effect of Malachite Green on Candida albicans involves multiple cellular pathways and is regulated by transcription regulators UPC2 and STP2 Antimicrobial Agents and Chemotherapy 56(1):495-506 2012

Conferences, Seminars &Talks

S.No. Details Year.
1 O12806“Recent Advances in Biochemistry and Biotechnology (RABB 2024)”, at University of Lucknow, on 16th March, 2024 2024
2 O12807“Functional Biology and Molecular Interactions (FBMI 2023)”, at University of Lucknow, on 28th January, 2023 2023
3 O12808“Recent Advances in Biochemistry and Biotechnology (RABB 2021)”, at University of Lucknow, on 20th March, 2021 2021
4 O12809FEMS Yeast Research Webinar on Yeast Lipids, FEMS, on 3rd June, 2021 2021
5 O12810“Two–day Workshop on finalization of Teaching Learning Resources for Life-science Teachers”, at NIEPA, New Delhi, on 16-17 Jan, 2020 2020
6 O12811International conference on “2nd Lipids in the Forefront: Lot more to discover” organized by Amity University, Gurgaon, from 12th – 13th December, 2019 2019
7 O12812“DST Inspire Camp” organized by S.R.M.S.C.E.T. Unnao, on September 2nd, 2019 2019
8 O12813Refresher Course in Chemistry & Bio-Chemistry held at Human Resource Development Center, University of Lucknow, Lucknow, Uttar Pradesh, India, August 17-31, 2019 2019
9 O12814Refresher Course in Chemistry & Bio-Chemistry held at Human Resource Development Center, University of Lucknow, Lucknow, Uttar Pradesh, India, August 17-31, 2019 2019
10 O12815"10th Conference on Yeast Biology" jointly organized by Jawaharlal Nehru University and Amity University, Gurgaon, held at JNU, New Delhi, India, 8th – 11th February, 2018 2018
11 O12816International Conference on “Conference on Functional Biology and Molecular Interactions (FBMI-2017)” held at University of Lucknow, Lucknow, Uttar Pradesh, India, 20th – 22nd December, 2017 2017
12 O12817“127th Orientation Program” (UGC, Govt. of India sponsored) held at Human Resource Development Center, University of Lucknow, Lucknow, Uttar Pradesh, India, 1st – 29th November, 2017 2017
13 O128186th National Conference on “Nanomaterials and Nanotechnology (NATCON NAMTECH VI)” held at Department of Physics, University of Lucknow, Lucknow, Uttar Pradesh, India, 11th – 13th February, 2017 2017
14 O12819National Conference “Lipids in forefront: A lot more to discover” held at Amity University, Panchgaon, Manesar, Gurgaon-122 413 (Haryana), India, 14th – 15th December, 2016 2016
15 O12820“57th Annual Conference & International Symposium of Association of Microbiologists of India” held at Gauhati University, Guwahati, India, 24th – 27th November, 2016 2016
16 O12821“National Seminar on: Paradigm Shifts in Biochemistry: Emerging Trends and New Vistas” held at University of Lucknow, Lucknow, UP, India, 10th September, 2016 2016
17 O12822“9th ICB&DD Symposium” held at Stony Brook University, Stony Brook, USA, 8th October, 2015 2015
18 O12823“114th ASM General Meeting” held at Boston, Massachusetts, USA, 17th – 20th May, 2014 2014
19 O12824“113th ASM General Meeting” held at Denver, Colorado, USA, 18th – 21st May, 2013 2013
20 O12825Workshop on ‘Scientific Writing and Bioethics’ held at School of Life Sciences, Jawaharlal Nehru University, New Delhi, India, 20th - 21st September, 2012 2012
21 O12826“Workshop on GCMS” held at Advanced Instrumentation Research Facility, Jawaharlal Nehru University, New Delhi, India, 13 – 14th August, 2012 2012
22 O12827“11th ASM Conference on Candida and Candidiasis” held at San Francisco, CA, USA, 29th March – 2nd April, 2012 2012

Awards & Recognitions

S.No. Name Of Awards Year.
1 O12802ASM Young Ambassador to India, American Society for Microbiology, USA 2013
2 O12803ASM Student travel award, American Society for Microbiology, USA 2012
3 O12805Senior Research Fellowship, Council of Scientific & Industrial Research, India 2012
4 O12804Travel award from Department of Science & Technology, India 2012

Academic/Administrative Services to the University

S.No. Details
1 O9143Member, Faculty Board, Faculty of Science, University of Lucknow (Present)
2 O9144Additional Dean, Research Cell, University of Lucknow (Past)
3 O9145Member, Board of Studies, Department of Biochemistry (Present)
4 O9146Assistant Proctor, University of Lucknow (Past)
5 O9147President, Table Tennis Club, University of Lucknow (Past)

Teaching Areas / Specialization

S.No. Details
1 O9127Biosafety and Bioethics
2 O9128Biochemical Techniques
3 O9129Immunology
4 O9130Cell Biology
5 O9131Fungal Infections
6 O9132Sphingolipids

Research Areas & Interests

S.No. Details
1 O9133DST Grant 2023: High throughput Lipidomics of Mucorales (black fungus) to determine specific lipid fingerprints associated with their infection and drug resistance
2 O9134CoE, UP Higher Education 2021: Targeting the lipid and iron homeostasis of Candida albicans to develop treatment approaches
3 O9135ASM, US 2009: Lipidomics of Candida in antifungal resistance
4 O9136ICMR Grant 2019: Manipulation of lipid biosynthesis to treat Trichophyton rubrum mediated onchomycosis
5 O9137DBT Grant 2020: A Mass Spectrometric Approach to Unravel the Landscape of Sphingolipids as Major Signaling Determinants of Drug Resistance and Virulence in Emerging Human Fungal Pathogen Candida auris
6 O9138Research & Development Grant, UP Higher Education 2024: Repurposing anti-cancer natural phytochemicals to treat human pathogenic Trichophyton species

Consulting Areas

S.No. Consulting Areas
1 O9139Sphingolipids
2 O9140Small and complex molecule mass spectrometry
3 O9141Human fungal infections
4 O9142Lipid metabolism