DR. ASHUTOSH SINGH

Assistant Professor

LIPID BIOCHEMISTRY AND INFECTIOUS DISEASES

Biochemistry

Basic Details

DR. ASHUTOSH SINGH
52012644
Assistant Professor
Biochemistry

Qualification Details

S.No. Qualification Name Of University Passing Year
1 Bachelor of Science University of Lucknow 2005
2 Master of Science University of Lucknow 2007
3 Doctor of Philosophy Jawaharlal Nehru University 2012

Positions Held

S.No. Employer Designation Employment Period
Date from Date to
1 O3860DBT, Govt. of India Senior Research Fellow 31/01/2013 30/10/2013
2 O3861State University of New York Postdoctoral Associate 06/12/2013 18/04/2016
3 O3862University of Lucknow Assistant Professor 22/04/2016 Presently Working

Academic Details

Recent Significant Publications, Articles, Cases

S.No. Title Journal Volume/Issue Year
1 O15292A Comprehensive Analysis of the Lipidomic Signatures in Rhizopus delemar Journal of Fungi doi: 10.20944/preprints202409.0325.v1 2024
2 O15231Aflatoxin B1 administration causes inflammation and apoptosis in the lungs and spleen Toxicon 107581, https://doi.org/10.1016/j.toxicon.2023.1 2024
3 O15288Application of the traditional spectrophotometric method for measuring cellular and free iron pools of Candida albicans Science and Innovation (Scientific Conferences) https://doi.org/10.5281/zenodo.13847121 2024
4 O15293Bisphenol A-induced oxidative stress increases the production of ovarian cancer stem cells in mice Reproductive Toxicology https://doi.org/10.1016/j.reprotox.2024. 2024
5 O15290Comparative evaluation of different methods for spore’s isolation from Trichophyton rubrum cultures Science and Innovation (Scientific Conferences) https://doi.org/10.5281/zenodo.13829100 2024
6 O15238Comparative Evaluation of Milk Oligosaccharides Isolated and Fractionated from Indigenous Rathi Cow Milk for Anti-Oxidant and Anti-Adhesive Properties Proceedings doi.org/10.3390/proceedings2024105047 2024
7 O15235Decoding the Complex Terrain of Candida tropicalis -Induced Candidiasis: Insights into Epidemiology, Infection Mechanisms,Therapeutics, and Drug Resistance Recent Advances in Human Fungal Diseases ISBN 978-981-97-4908-9 2024
8 O15294Drug resistance in Mycobacterium tuberculosis: an evolutionary perspective and its adaptation to the lung microenvironment The Microbe doi.org/10.1016/j.microb.2024.100189 2024
9 O15291Future perspective of metabolomic study in dermatophyte cultures Science and Innovation (Scientific Conferences) https://doi.org/10.5281/zenodo.13832344 2024
10 O15234Impact of sphingolipid synthesis inhibition on the drug susceptibility patterns of Trichophyton species Diagnostic Microbiology & Infectious Disease 116283 2024
11 O15236Mucormycosis Infection and Methods of Detection: An Overview Human Fungal Diseases https://doi.org/10.1201/9781032642864 2024
12 O15287Optimized Purification Processes for Isolation and Modification of Oligosaccharides from Rathi Cow’s Milk Foods sciforum-103248 2024
13 O15232Remodeling of membrane lipid homeostasis in azole resistant isolates of Candida albicans Chemical Biology Letters 11(2), 658 2024
14 O15233Sphingolipid diversity in Candida auris: unraveling interclade and drug resistance fingerprints FEMS Yeast Research foae008 2024
15 O15289Suitability of Ftr2 (iron permease) for screening of antifungal compounds against Candida albicans Science and Innovation (Scientific Conferences) https://doi.org/10.5281/zenodo.13831907 2024
16 O15237Understanding Trichophyton-Mediated Dermatophytosis: Key Factors and Treatment Insights Human Fungal Diseases https://doi.org/10.1201/9781032642864 2024
17 O15242Beyond Membrane Components: Uncovering the Intriguing World of Fungal Sphingolipid Synthesis and Regulation Research in Microbiology 174(7), 104087, https://doi.org/10.1016/j.resmic.2023.104087 2023
18 O15240Metabolomics and therapeutic potential of Ophiocordyceps sinensis Phytochemical Genomics: Plant Metabolomics and Medicinal Plant Genomics 319–342; DOI:10.1007/978-981-19-5779-6_12 2023
19 O15239Microevolution of clade II isolates of Candida auris highlights multifaceted intra-clade heterogeneity in acquiring resistance towards amphotericin B bioRxiv https://doi.org/10.1101/2023.09.20.558730 2023
20 O15241Polydispersed Acid-Functionalized Single-Walled Carbon Nanotubes Induced the Integrin-Associated Protein (CD47) and Basigin (CD147) Expression and Modulated the Antioxidant Gene Expression in Erythroi BioNanoScience doi.org/10.1007/s12668-023-01071-8 2023
21 O15246Epidemiology and Therapeutics strategies to treat human pathogenic coronaviruses disease Novel Corona Virus (COVID-19) Past, Present and Future, UCOST, ISBN: 978-93-93097-97-2 361-372 2022
22 O15243High-Throughput Phospholipidomics of Candida Cells: From Sample Preparation to Data Analysis Candida Species: Methods and Protocols 127-140 2022
23 O15244Inositol Phosphoryl Transferase, Ipt1, Is a Critical Determinant of Azole Resistance and Virulence Phenotypes in Candida glabrata Journal of Fungi 8(7), 651; https://doi.org/10.3390/jof80 2022
24 O15245Paraquat treatment modulates the stress erythropoiesis response in bone marrow and liver of splenectomized mice Chemical Biology Letters 9,2:306 2022
25 O15251Cholesterol and sphingomyelin are critical for Fcγ receptor-mediated phagocytosis of Cryptococcus neoformans by macrophages Journal of Biological Chemistry https://doi.org/10.1016/j.jbc.2021.10141 2021
26 O15248Lipid Structure, Function, and Lipidomic Applications In: Hameed S., Fatima Z. (eds) Integrated Omics Approaches to Infectious Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-16-0691-5_24 2021
27 O15247Mass Spectrometric Analysis of Bioactive Sphingolipids in Fungi In: Hsu FF. (eds) Mass Spectrometry-Based Lipidomics. Methods in Molecular Biology, Humana, New York, NY. 2306, https://doi.org/10.1007/978-1-0716-1410-5_16 2021
28 O15250Sphingolipidomics of drug resistant Candida auris clinical isolates reveal distinct sphingolipid species signatures Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1866(1):158815 2021
29 O15257A detailed lipidomic study of human pathogenic fungi Candida auris FEMS Yeast Research https://doi.org/10.1093/femsyr/foaa045 2020
30 O15254Analysis of Membrane Lipids *Book, Springer, New York, NY 1, ISBN:978-1-0716-0631-5; 2020
31 O15253Analysis of Sterols by Gas Chromatography–Mass Spectrometry Analysis of Membrane Lipids, Springer, New York, NY 1:83-101, ISBN: 978-1-0716-0631-5 2020
32 O15252Background of Membrane Lipids Analysis of Membrane Lipids, Springer, New York, NY 1:1-11, ISBN: 78-1-0716-0631-5 2020
33 O15255Nanomaterial-Assisted Mass Spectrometry: An Evolving Cutting-Edge Technique NanoBioMedicine. Springer, Singapore https://doi.org/10.1007/978-981-32-9898-9_19; pp 453-464 2020
34 O15256Splenectomy modulates the erythrocyte turnover and Basigin (CD147) expression in mice Indian Journal of Hematology and Blood Transfusion https://doi.org/10.1007/s12288-020-01272-1 2020
35 O15259Lipidomics Approaches: Applied to the Study of Pathogenesis in Candida Species Yeasts in Biotechnology and Human Health. Progress in Molecular and Subcellular Biology, Springer Cham 58:195-215 2019
36 O15258Sphingolipid Biosynthetic Pathway is Crucial for Growth, Biofilm Formation and Membrane Integrity of Scedosporium boydii Future Medicinal Chemistry https://doi.org/10.4155/fmc-2019-0186 2019
37 O15262Azole resistance in a Candida albicans mutant lacking the ABC transporter CDR6/ROA1 depends on TOR signaling Journal of Biological Chemistry 293(2):412-432 2018
38 O15261Paraquat treatment modulates Integrin associated Protein (CD47) and Basigin (CD147) expression and mitochondrial potential on erythroid cells in mice Environmental Toxicology and Pharmacology 58:37-44 2018
39 O15260The role of ceramide synthases in the pathogenicity of Cryptococcus neoformans Cell Reports 22(6):1392-1400 2018
40 O15265Analysis of sphingolipids, sterols and phospholipids in human pathogenic Cryptococcus strains Journal of Lipid Research 58(10):2017-2036 2017
41 O15264Changes in Glucosylceramide Structure Affect Virulence and Membrane Biophysical Properties of Cryptococcus neoformans Biochimica et Biophysica Acta - Biomembranes 1859:2224–2233 2017
42 O15263Comparison of TLC and GCMS techniques for steryl glucoside analysis International Journal of Scientific Research Letters 1(1):17-20 2017
43 O15267Insights into Candida lipids Candida albicans: Cellular and Molecular Biology, Springer 978-3-319-50409-4 2017
44 O15266The effect of sterol structure upon clathrin-mediated and clathrin-independent endocytosis Journal of Cell Science 130:2682-2695 2017
45 O15269Functional characterization of the Aspergillus nidulans glucosylceramide pathway reveals that LCB Δ8‐desaturation and C9‐methylation are relevant to filamentous growth, lipid raft localization and Psd Molecular Microbiology 102(3):488-505 2016
46 O15271Glucosylceramide Administration as a Vaccination Strategy in Mouse Models of Cryptococcosis PLOS ONE 11(4):e0153853 2016
47 O15272Pleiotropic effects of a vacuolar ABC transporter MLT1 of Candida albicans on cell function and virulence Biochemical Journal 473(11):1537-52 2016
48 O15249Sphingolipidomics: an important mechanistic tool for studying fungal pathogens Frontiers in Microbiology 7:501 2016
49 O15268Sphingolipids: the most recent target for fungal infections treatment Future Medicinal Chemistry 8(12):1469-1484 2016
50 O15270The Aspergillus fumigatus SchASCH9 kinase modulates SakAHOG1 MAP kinase activity and it is essential for virulence Molecular Microbiology 102(4):642-671 2016
51 O15275Identification of a new class of antifungals targeting the synthesis of fungal sphingolipids mBio 6(3):e00647 2015
52 O15273Qualitative and quantitative measurements of sphingolipids by mass spectrometry Bioactive Sphingolipids in Cancer Biology and Therapy (Springer Science) 978-3-319-20750-6 2015
53 O15274Role of Sterylglucosidase 1 (Sgl1) on the pathogenicity of Cryptococcus neoformans: potential applications for vaccine development Frontiers in Microbiology 6:836 2015
54 O15276An assessment of growth media enrichment on lipid metabolome and the concurrent phenotypic properties of Candida albicans PLOS ONE 11:e113664 2014
55 O15280Curcumin targets cell wall integrity via calcineurin mediated signaling in Candida albicans Antimicrobial Agents and Chemotherapy 58(1):167-75 2014
56 O15277Inositol Phosphosphingolipid Phospholipase C1 Regulates Plasma Membrane ATPase (Pma1) Stability in Cryptococcus neoformans FEBS Letters 558(21):3932-3938 2014
57 O15279Novel Role of a Family of Major Facilitator Transporters in Biofilm Development and Virulence of Candida albicans Biochemical Journal 460(2):223-235 2014
58 O15278What are the opportunities and responsibilities of scientists to communicate their research at home and abroad? Cultures (ASM, USA) 1(2):52-59 2014
59 O15282Lipidomics and in vitro azole resistance in Candida albicans OMICS 17(2):84-93 2013
60 O15281Lipids of Candida albicans and their role in multidrug resistance Current Genetics 59(4):243-50 2013
61 O15283A key structural domain of the Candida albicans Mdr1 protein Biochemical Journal 445(3):313-22 2012
62 O15284Comparative lipidomics in clinical isolates of Candida albicans reveal crosstalk between mitochondria, cell wall integrity and azole resistance PLOS ONE 7(6):e39812 2012
63 O15286Lipidome analysis reveals antifungal polyphenol curcumin affects membrane lipid homeostasis Frontiers in Bioscience (Elite Ed) 4:1195-209 2012
64 O15285The antifungal effect of Malachite Green on Candida albicans involves multiple cellular pathways and is regulated by transcription regulators UPC2 and STP2 Antimicrobial Agents and Chemotherapy 56(1):495-506 2012

Conferences, Seminars &Talks

S.No. Details Year.
1 O14482“Recent Advances in Biochemistry and Biotechnology (RABB 2024)”, at University of Lucknow, on 16th March, 2024 2024
2 O14483“Functional Biology and Molecular Interactions (FBMI 2023)”, at University of Lucknow, on 28th January, 2023 2023
3 O14484“Recent Advances in Biochemistry and Biotechnology (RABB 2021)”, at University of Lucknow, on 20th March, 2021 2021
4 O14485FEMS Yeast Research Webinar on Yeast Lipids, FEMS, on 3rd June, 2021 2021
5 O14486“Two–day Workshop on finalization of Teaching Learning Resources for Life-science Teachers”, at NIEPA, New Delhi, on 16-17 Jan, 2020 2020
6 O14487International conference on “2nd Lipids in the Forefront: Lot more to discover” organized by Amity University, Gurgaon, from 12th – 13th December, 2019 2019
7 O14488“DST Inspire Camp” organized by S.R.M.S.C.E.T. Unnao, on September 2nd, 2019 2019
8 O14489Refresher Course in Chemistry & Bio-Chemistry held at Human Resource Development Center, University of Lucknow, Lucknow, Uttar Pradesh, India, August 17-31, 2019 2019
9 O14490Refresher Course in Chemistry & Bio-Chemistry held at Human Resource Development Center, University of Lucknow, Lucknow, Uttar Pradesh, India, August 17-31, 2019 2019
10 O14491"10th Conference on Yeast Biology" jointly organized by Jawaharlal Nehru University and Amity University, Gurgaon, held at JNU, New Delhi, India, 8th – 11th February, 2018 2018
11 O14492International Conference on “Conference on Functional Biology and Molecular Interactions (FBMI-2017)” held at University of Lucknow, Lucknow, Uttar Pradesh, India, 20th – 22nd December, 2017 2017
12 O14493“127th Orientation Program” (UGC, Govt. of India sponsored) held at Human Resource Development Center, University of Lucknow, Lucknow, Uttar Pradesh, India, 1st – 29th November, 2017 2017
13 O144946th National Conference on “Nanomaterials and Nanotechnology (NATCON NAMTECH VI)” held at Department of Physics, University of Lucknow, Lucknow, Uttar Pradesh, India, 11th – 13th February, 2017 2017
14 O14495National Conference “Lipids in forefront: A lot more to discover” held at Amity University, Panchgaon, Manesar, Gurgaon-122 413 (Haryana), India, 14th – 15th December, 2016 2016
15 O14496“57th Annual Conference & International Symposium of Association of Microbiologists of India” held at Gauhati University, Guwahati, India, 24th – 27th November, 2016 2016
16 O14497“National Seminar on: Paradigm Shifts in Biochemistry: Emerging Trends and New Vistas” held at University of Lucknow, Lucknow, UP, India, 10th September, 2016 2016
17 O14498“9th ICB&DD Symposium” held at Stony Brook University, Stony Brook, USA, 8th October, 2015 2015
18 O14499“114th ASM General Meeting” held at Boston, Massachusetts, USA, 17th – 20th May, 2014 2014
19 O14500“113th ASM General Meeting” held at Denver, Colorado, USA, 18th – 21st May, 2013 2013
20 O14501Workshop on ‘Scientific Writing and Bioethics’ held at School of Life Sciences, Jawaharlal Nehru University, New Delhi, India, 20th - 21st September, 2012 2012
21 O14502“Workshop on GCMS” held at Advanced Instrumentation Research Facility, Jawaharlal Nehru University, New Delhi, India, 13 – 14th August, 2012 2012
22 O14503“11th ASM Conference on Candida and Candidiasis” held at San Francisco, CA, USA, 29th March – 2nd April, 2012 2012

Awards & Recognitions

S.No. Name Of Awards Year.
1 O14478ASM Young Ambassador to India, American Society for Microbiology, USA 2013
2 O14479ASM Student travel award, American Society for Microbiology, USA 2012
3 O14481Senior Research Fellowship, Council of Scientific & Industrial Research, India 2012
4 O14480Travel award from Department of Science & Technology, India 2012

Academic/Administrative Services to the University

S.No. Details
1 O10489Member, Faculty Board, Faculty of Science, University of Lucknow (Present)
2 O10490Additional Dean, Research Cell, University of Lucknow (Past)
3 O10491Member, Board of Studies, Department of Biochemistry (Present)
4 O10492Assistant Proctor, University of Lucknow (Past)
5 O10493President, Table Tennis Club, University of Lucknow (Past)

Teaching Areas / Specialization

S.No. Details
1 O10473Biosafety and Bioethics
2 O10474Biochemical Techniques
3 O10475Immunology
4 O10476Cell Biology
5 O10477Fungal Infections
6 O10478Sphingolipids

Research Areas & Interests

S.No. Details
1 O10479DST Grant 2023: High throughput Lipidomics of Mucorales (black fungus) to determine specific lipid fingerprints associated with their infection and drug resistance
2 O10480CoE, UP Higher Education 2021: Targeting the lipid and iron homeostasis of Candida albicans to develop treatment approaches
3 O10481ASM, US 2009: Lipidomics of Candida in antifungal resistance
4 O10482ICMR Grant 2019: Manipulation of lipid biosynthesis to treat Trichophyton rubrum mediated onchomycosis
5 O10483DBT Grant 2020: A Mass Spectrometric Approach to Unravel the Landscape of Sphingolipids as Major Signaling Determinants of Drug Resistance and Virulence in Emerging Human Fungal Pathogen Candida auris
6 O10484Research & Development Grant, UP Higher Education 2024: Repurposing anti-cancer natural phytochemicals to treat human pathogenic Trichophyton species

Consulting Areas

S.No. Consulting Areas
1 O10485Sphingolipids
2 O10486Small and complex molecule mass spectrometry
3 O10487Human fungal infections
4 O10488Lipid metabolism