DR. ASHUTOSH SINGH

Assistant Professor

LIPID BIOCHEMISTRY AND INFECTIOUS DISEASES

Biochemistry

Basic Details

DR. ASHUTOSH SINGH
52012644
Assistant Professor
Biochemistry

Qualification Details

S.No. Qualification Name Of University Passing Year
1 Bachelor of Science University of Lucknow 2005
2 Master of Science University of Lucknow 2007
3 Doctor of Philosophy Jawaharlal Nehru University 2012

Positions Held

S.No. Employer Designation Employment Period
Date from Date to
1 O4384DBT, Govt. of India Senior Research Fellow 31/01/2013 30/10/2013
2 O4385State University of New York Postdoctoral Associate 06/12/2013 18/04/2016
3 O4386University of Lucknow Assistant Professor 22/04/2016 Presently Working

Academic Details

Recent Significant Publications, Articles, Cases

S.No. Title Journal Volume/Issue Year
1 O18080Benzo (a)pyrene exposure reduces CD54 expression on alveolar macrophages and alters apoptosis and inflammatory responses in the lungs Indian Journal of Biochemistry & Biophysics DOI: 10.56042/ijbb.v62i6.10703 2025
2 O18081Bisphenol-A-induced ovarian cancer: Changes in epithelial diversity, apoptosis, antioxidant and anti-inflammatory mechanisms Reproductive Toxicology 135:108909 2025
3 O18085Bisphenol-A-induced ovarian cancer: Changes in epithelial diversity, apoptosis, antioxidant and anti-inflammatory mechanisms Reproductive Toxicology https://doi.org/10.1016/j.reprotox.2025.108909 2025
4 O18153CD47/SIRPα pathways: Functional diversity and molecular mechanisms World Journal of Biological Chemistry DOI: 10.4331/wjbc.v16.i3.108045 2025
5 O18084Dermatophytosis in context of Trichophyton rubrum: host defense mechanisms, virulence factors, and treatment innovations Molecular Biology Reports https://doi.org/10.1007/s11033-025-10744-4 2025
6 O18079Diversity in the lipidomes of Trichophyton rubrum, Trichophyton interdigitale and Trichophyton tonsurans, and their phenotypes Microbial Pathogenesis https://doi.org/10.1016/j.micpath.2025.1 2025
7 O18086Mass Spectrometry-Based Lipidomics Reveals a Strong Connection Between Lipid Homeostasis and Iron Acquisition in Candida albicans Lipids https://doi.org/10.1002/lipd.12455 2025
8 O18087Multi-Omics Analysis of Experimentally Evolved Candida auris Isolates Reveals Modulation of Sterols, Sphingolipids, and Oxidative Stress in Acquired Amphotericin B Resistance Molecular microbiology https://doi.org/10.1111/mmi.15379 2025
9 O18083Optimized Purification Processes for Isolation and Modification of Oligosaccharides from Rathi Cow’s Milk Biol. Life Sci. Forum https://doi.org/10.3390/blsf2024040021 2025
10 O18082The experimentally evolved fluconazole-resistant clade II isolates of Candidozyma auris exhibit a distinct lipid compositional landscape, highlighting intraclade sphingolipid heterogeneity FEMS Yeast Research https://doi.org/10.1093/femsyr/foaf030 2025
11 O18102A Comprehensive Analysis of the Lipidomic Signatures in Rhizopus delemar Journal of Fungi doi: 10.20944/preprints202409.0325.v1 2024
12 O18090Aflatoxin B1 administration causes inflammation and apoptosis in the lungs and spleen Toxicon 107581, https://doi.org/10.1016/j.toxicon.2023.1 2024
13 O18098Application of the traditional spectrophotometric method for measuring cellular and free iron pools of Candida albicans Science and Innovation (Scientific Conferences) https://doi.org/10.5281/zenodo.13847121 2024
14 O18089Benzo (A) Pyrene exposure alters Alveolar Epithelial and Macrophage Cells diversity and induces antioxidant responses in lungs Toxicology Reports https://doi.org/10.1016/j.toxrep.2024.10 2024
15 O18103Bisphenol A-induced oxidative stress increases the production of ovarian cancer stem cells in mice Reproductive Toxicology https://doi.org/10.1016/j.reprotox.2024. 2024
16 O18100Comparative evaluation of different methods for spore’s isolation from Trichophyton rubrum cultures Science and Innovation (Scientific Conferences) https://doi.org/10.5281/zenodo.13829100 2024
17 O18097Comparative Evaluation of Milk Oligosaccharides Isolated and Fractionated from Indigenous Rathi Cow Milk for Anti-Oxidant and Anti-Adhesive Properties Proceedings doi.org/10.3390/proceedings2024105047 2024
18 O18094Decoding the Complex Terrain of Candida tropicalis -Induced Candidiasis: Insights into Epidemiology, Infection Mechanisms,Therapeutics, and Drug Resistance Recent Advances in Human Fungal Diseases ISBN 978-981-97-4908-9 2024
19 O18104Drug resistance in Mycobacterium tuberculosis: an evolutionary perspective and its adaptation to the lung microenvironment The Microbe doi.org/10.1016/j.microb.2024.100189 2024
20 O18101Future perspective of metabolomic study in dermatophyte cultures Science and Innovation (Scientific Conferences) https://doi.org/10.5281/zenodo.13832344 2024
21 O18093Impact of sphingolipid synthesis inhibition on the drug susceptibility patterns of Trichophyton species Diagnostic Microbiology & Infectious Disease 116283 2024
22 O18088Modulation of redox metabolism, CD147, and CD47 expression with the maturation of hematopoietic stem cells in bone marrow Indian Journal of Hematology and Blood Transfusion https://doi.org/10.1007/s12288-024-01911-x 2024
23 O18095Mucormycosis Infection and Methods of Detection: An Overview Human Fungal Diseases https://doi.org/10.1201/9781032642864 2024
24 O18091Remodeling of membrane lipid homeostasis in azole resistant isolates of Candida albicans Chemical Biology Letters 11(2), 658 2024
25 O18092Sphingolipid diversity in Candida auris: unraveling interclade and drug resistance fingerprints FEMS Yeast Research foae008 2024
26 O18099Suitability of Ftr2 (iron permease) for screening of antifungal compounds against Candida albicans Science and Innovation (Scientific Conferences) https://doi.org/10.5281/zenodo.13831907 2024
27 O18096Understanding Trichophyton-Mediated Dermatophytosis: Key Factors and Treatment Insights Human Fungal Diseases https://doi.org/10.1201/9781032642864 2024
28 O18108Beyond Membrane Components: Uncovering the Intriguing World of Fungal Sphingolipid Synthesis and Regulation Research in Microbiology 174(7), 104087, https://doi.org/10.1016/j.resmic.2023.104087 2023
29 O18106Metabolomics and therapeutic potential of Ophiocordyceps sinensis Phytochemical Genomics: Plant Metabolomics and Medicinal Plant Genomics 319–342; DOI:10.1007/978-981-19-5779-6_12 2023
30 O18105Microevolution of clade II isolates of Candida auris highlights multifaceted intra-clade heterogeneity in acquiring resistance towards amphotericin B bioRxiv https://doi.org/10.1101/2023.09.20.558730 2023
31 O18107Polydispersed Acid-Functionalized Single-Walled Carbon Nanotubes Induced the Integrin-Associated Protein (CD47) and Basigin (CD147) Expression and Modulated the Antioxidant Gene Expression in Erythroi BioNanoScience doi.org/10.1007/s12668-023-01071-8 2023
32 O18112Epidemiology and Therapeutics strategies to treat human pathogenic coronaviruses disease Novel Corona Virus (COVID-19) Past, Present and Future, UCOST, ISBN: 978-93-93097-97-2 361-372 2022
33 O18109High-Throughput Phospholipidomics of Candida Cells: From Sample Preparation to Data Analysis Candida Species: Methods and Protocols 127-140 2022
34 O18110Inositol Phosphoryl Transferase, Ipt1, Is a Critical Determinant of Azole Resistance and Virulence Phenotypes in Candida glabrata Journal of Fungi 8(7), 651; https://doi.org/10.3390/jof80 2022
35 O18111Paraquat treatment modulates the stress erythropoiesis response in bone marrow and liver of splenectomized mice Chemical Biology Letters 9,2:306 2022
36 O18116Cholesterol and sphingomyelin are critical for Fcγ receptor-mediated phagocytosis of Cryptococcus neoformans by macrophages Journal of Biological Chemistry https://doi.org/10.1016/j.jbc.2021.10141 2021
37 O18114Lipid Structure, Function, and Lipidomic Applications In: Hameed S., Fatima Z. (eds) Integrated Omics Approaches to Infectious Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-16-0691-5_24 2021
38 O18113Mass Spectrometric Analysis of Bioactive Sphingolipids in Fungi In: Hsu FF. (eds) Mass Spectrometry-Based Lipidomics. Methods in Molecular Biology, Humana, New York, NY. 2306, https://doi.org/10.1007/978-1-0716-1410-5_16 2021
39 O18115Sphingolipidomics of drug resistant Candida auris clinical isolates reveal distinct sphingolipid species signatures Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1866(1):158815 2021
40 O18122A detailed lipidomic study of human pathogenic fungi Candida auris FEMS Yeast Research https://doi.org/10.1093/femsyr/foaa045 2020
41 O18119Analysis of Membrane Lipids *Book, Springer, New York, NY 1, ISBN:978-1-0716-0631-5; 2020
42 O18118Analysis of Sterols by Gas Chromatography–Mass Spectrometry Analysis of Membrane Lipids, Springer, New York, NY 1:83-101, ISBN: 978-1-0716-0631-5 2020
43 O18117Background of Membrane Lipids Analysis of Membrane Lipids, Springer, New York, NY 1:1-11, ISBN: 78-1-0716-0631-5 2020
44 O18120Nanomaterial-Assisted Mass Spectrometry: An Evolving Cutting-Edge Technique NanoBioMedicine. Springer, Singapore https://doi.org/10.1007/978-981-32-9898-9_19; pp 453-464 2020
45 O18121Splenectomy modulates the erythrocyte turnover and Basigin (CD147) expression in mice Indian Journal of Hematology and Blood Transfusion https://doi.org/10.1007/s12288-020-01272-1 2020
46 O18124Lipidomics Approaches: Applied to the Study of Pathogenesis in Candida Species Yeasts in Biotechnology and Human Health. Progress in Molecular and Subcellular Biology, Springer Cham 58:195-215 2019
47 O18123Sphingolipid Biosynthetic Pathway is Crucial for Growth, Biofilm Formation and Membrane Integrity of Scedosporium boydii Future Medicinal Chemistry https://doi.org/10.4155/fmc-2019-0186 2019
48 O18127Azole resistance in a Candida albicans mutant lacking the ABC transporter CDR6/ROA1 depends on TOR signaling Journal of Biological Chemistry 293(2):412-432 2018
49 O18126Paraquat treatment modulates Integrin associated Protein (CD47) and Basigin (CD147) expression and mitochondrial potential on erythroid cells in mice Environmental Toxicology and Pharmacology 58:37-44 2018
50 O18125The role of ceramide synthases in the pathogenicity of Cryptococcus neoformans Cell Reports 22(6):1392-1400 2018
51 O18130Analysis of sphingolipids, sterols and phospholipids in human pathogenic Cryptococcus strains Journal of Lipid Research 58(10):2017-2036 2017
52 O18129Changes in Glucosylceramide Structure Affect Virulence and Membrane Biophysical Properties of Cryptococcus neoformans Biochimica et Biophysica Acta - Biomembranes 1859:2224–2233 2017
53 O18128Comparison of TLC and GCMS techniques for steryl glucoside analysis International Journal of Scientific Research Letters 1(1):17-20 2017
54 O18132Insights into Candida lipids Candida albicans: Cellular and Molecular Biology, Springer 978-3-319-50409-4 2017
55 O18131The effect of sterol structure upon clathrin-mediated and clathrin-independent endocytosis Journal of Cell Science 130:2682-2695 2017
56 O18134Functional characterization of the Aspergillus nidulans glucosylceramide pathway reveals that LCB Δ8‐desaturation and C9‐methylation are relevant to filamentous growth, lipid raft localization and Psd Molecular Microbiology 102(3):488-505 2016
57 O18136Glucosylceramide Administration as a Vaccination Strategy in Mouse Models of Cryptococcosis PLOS ONE 11(4):e0153853 2016
58 O18137Pleiotropic effects of a vacuolar ABC transporter MLT1 of Candida albicans on cell function and virulence Biochemical Journal 473(11):1537-52 2016
59 O18138Sphingolipidomics: an important mechanistic tool for studying fungal pathogens Frontiers in Microbiology 7:501 2016
60 O18133Sphingolipids: the most recent target for fungal infections treatment Future Medicinal Chemistry 8(12):1469-1484 2016
61 O18135The Aspergillus fumigatus SchASCH9 kinase modulates SakAHOG1 MAP kinase activity and it is essential for virulence Molecular Microbiology 102(4):642-671 2016
62 O18141Identification of a new class of antifungals targeting the synthesis of fungal sphingolipids mBio 6(3):e00647 2015
63 O18139Qualitative and quantitative measurements of sphingolipids by mass spectrometry Bioactive Sphingolipids in Cancer Biology and Therapy (Springer Science) 978-3-319-20750-6 2015
64 O18140Role of Sterylglucosidase 1 (Sgl1) on the pathogenicity of Cryptococcus neoformans: potential applications for vaccine development Frontiers in Microbiology 6:836 2015
65 O18142An assessment of growth media enrichment on lipid metabolome and the concurrent phenotypic properties of Candida albicans PLOS ONE 11:e113664 2014
66 O18146Curcumin targets cell wall integrity via calcineurin mediated signaling in Candida albicans Antimicrobial Agents and Chemotherapy 58(1):167-75 2014
67 O18143Inositol Phosphosphingolipid Phospholipase C1 Regulates Plasma Membrane ATPase (Pma1) Stability in Cryptococcus neoformans FEBS Letters 558(21):3932-3938 2014
68 O18145Novel Role of a Family of Major Facilitator Transporters in Biofilm Development and Virulence of Candida albicans Biochemical Journal 460(2):223-235 2014
69 O18144What are the opportunities and responsibilities of scientists to communicate their research at home and abroad? Cultures (ASM, USA) 1(2):52-59 2014
70 O18147Lipidomics and in vitro azole resistance in Candida albicans OMICS 17(2):84-93 2013
71 O18148Lipids of Candida albicans and their role in multidrug resistance Current Genetics 59(4):243-50 2013
72 O18149A key structural domain of the Candida albicans Mdr1 protein Biochemical Journal 445(3):313-22 2012
73 O18150Comparative lipidomics in clinical isolates of Candida albicans reveal crosstalk between mitochondria, cell wall integrity and azole resistance PLOS ONE 7(6):e39812 2012
74 O18152Lipidome analysis reveals antifungal polyphenol curcumin affects membrane lipid homeostasis Frontiers in Bioscience (Elite Ed) 4:1195-209 2012
75 O18151The antifungal effect of Malachite Green on Candida albicans involves multiple cellular pathways and is regulated by transcription regulators UPC2 and STP2 Antimicrobial Agents and Chemotherapy 56(1):495-506 2012

Conferences, Seminars &Talks

S.No. Details Year.
1 O16195“Recent Advances in Biochemistry and Biotechnology (RABB 2024)”, at University of Lucknow, on 16th March, 2024 2024
2 O16196“Functional Biology and Molecular Interactions (FBMI 2023)”, at University of Lucknow, on 28th January, 2023 2023
3 O16217“Yeast India 2023: Fundamental to Applications of Yeast and Fungi” held from March 10-13, 2023 at IISER Mohali 2023
4 O16197“Recent Advances in Biochemistry and Biotechnology (RABB 2021)”, at University of Lucknow, on 20th March, 2021 2021
5 O16198FEMS Yeast Research Webinar on Yeast Lipids, FEMS, on 3rd June, 2021 2021
6 O16199“Two–day Workshop on finalization of Teaching Learning Resources for Life-science Teachers”, at NIEPA, New Delhi, on 16-17 Jan, 2020 2020
7 O16200International conference on “2nd Lipids in the Forefront: Lot more to discover” organized by Amity University, Gurgaon, from 12th – 13th December, 2019 2019
8 O16201“DST Inspire Camp” organized by S.R.M.S.C.E.T. Unnao, on September 2nd, 2019 2019
9 O16202Refresher Course in Chemistry & Bio-Chemistry held at Human Resource Development Center, University of Lucknow, Lucknow, Uttar Pradesh, India, August 17-31, 2019 2019
10 O16203Refresher Course in Chemistry & Bio-Chemistry held at Human Resource Development Center, University of Lucknow, Lucknow, Uttar Pradesh, India, August 17-31, 2019 2019
11 O16204"10th Conference on Yeast Biology" jointly organized by Jawaharlal Nehru University and Amity University, Gurgaon, held at JNU, New Delhi, India, 8th – 11th February, 2018 2018
12 O16205International Conference on “Conference on Functional Biology and Molecular Interactions (FBMI-2017)” held at University of Lucknow, Lucknow, Uttar Pradesh, India, 20th – 22nd December, 2017 2017
13 O16206“127th Orientation Program” (UGC, Govt. of India sponsored) held at Human Resource Development Center, University of Lucknow, Lucknow, Uttar Pradesh, India, 1st – 29th November, 2017 2017
14 O162076th National Conference on “Nanomaterials and Nanotechnology (NATCON NAMTECH VI)” held at Department of Physics, University of Lucknow, Lucknow, Uttar Pradesh, India, 11th – 13th February, 2017 2017
15 O16208National Conference “Lipids in forefront: A lot more to discover” held at Amity University, Panchgaon, Manesar, Gurgaon-122 413 (Haryana), India, 14th – 15th December, 2016 2016
16 O16209“57th Annual Conference & International Symposium of Association of Microbiologists of India” held at Gauhati University, Guwahati, India, 24th – 27th November, 2016 2016
17 O16210“National Seminar on: Paradigm Shifts in Biochemistry: Emerging Trends and New Vistas” held at University of Lucknow, Lucknow, UP, India, 10th September, 2016 2016
18 O16211“9th ICB&DD Symposium” held at Stony Brook University, Stony Brook, USA, 8th October, 2015 2015
19 O16212“114th ASM General Meeting” held at Boston, Massachusetts, USA, 17th – 20th May, 2014 2014
20 O16213“113th ASM General Meeting” held at Denver, Colorado, USA, 18th – 21st May, 2013 2013
21 O16214Workshop on ‘Scientific Writing and Bioethics’ held at School of Life Sciences, Jawaharlal Nehru University, New Delhi, India, 20th - 21st September, 2012 2012
22 O16215“Workshop on GCMS” held at Advanced Instrumentation Research Facility, Jawaharlal Nehru University, New Delhi, India, 13 – 14th August, 2012 2012
23 O16216“11th ASM Conference on Candida and Candidiasis” held at San Francisco, CA, USA, 29th March – 2nd April, 2012 2012

Awards & Recognitions

S.No. Name Of Awards Year.
1 O16191ASM Young Ambassador to India, American Society for Microbiology, USA 2013
2 O16192ASM Student travel award, American Society for Microbiology, USA 2012
3 O16194Senior Research Fellowship, Council of Scientific & Industrial Research, India 2012
4 O16193Travel award from Department of Science & Technology, India 2012

Academic/Administrative Services to the University

S.No. Details
1 O12113Member, Faculty Board, Faculty of Science, University of Lucknow (Present)
2 O12114Additional Dean, Research Cell, University of Lucknow (Past)
3 O12115Member, Board of Studies, Department of Biochemistry (Present)
4 O12116Assistant Proctor, University of Lucknow (Past)
5 O12117President, Table Tennis Club, University of Lucknow (Past)

Teaching Areas / Specialization

S.No. Details
1 O12101Biosafety and Bioethics
2 O12102Biochemical Techniques
3 O12103Immunology
4 O12104Cell Biology
5 O12105Fungal Infections
6 O12106Sphingolipids

Research Areas & Interests

S.No. Details
1 O12107DST Grant 2023: High throughput Lipidomics of Mucorales (black fungus) to determine specific lipid fingerprints associated with their infection and drug resistance
2 O12108CoE, UP Higher Education 2021: Targeting the lipid and iron homeostasis of Candida albicans to develop treatment approaches
3 O12109ASM, US 2009: Lipidomics of Candida in antifungal resistance
4 O12110ICMR Grant 2019: Manipulation of lipid biosynthesis to treat Trichophyton rubrum mediated onchomycosis
5 O12111DBT Grant 2020: A Mass Spectrometric Approach to Unravel the Landscape of Sphingolipids as Major Signaling Determinants of Drug Resistance and Virulence in Emerging Human Fungal Pathogen Candida auris
6 O12112Research & Development Grant, UP Higher Education 2024: Repurposing anti-cancer natural phytochemicals to treat human pathogenic Trichophyton species

Consulting Areas

S.No. Consulting Areas
1 O12118Sphingolipids
2 O12119Small and complex molecule mass spectrometry
3 O12120Human fungal infections
4 O12121Lipid metabolism